Indwara zidakira zimpyiko (CKD) zikunze kugira hyperphosphatemia, kandi hyperphosphatemia igihe kirekire irashobora gutera ingorane zikomeye nka hyperparathyideyide ya kabiri, osteodystrophy yimpyiko, n'indwara z'umutima. Kugenzura urugero rwa fosifore mu maraso ni igice cyingenzi mu micungire y’abarwayi ba CKD, kandi guhuza fosifate niwo muti wibanze wo kuvura hyperphosphatemia. Mu myaka yashize,lanthanum karubone, nk'ubwoko bushya bwa calcium na non-aluminium fosifate, buhoro buhoro bwinjiye mubyerekezo byabantu kandi butangira "amarushanwa" hamwe na fosifate gakondo.
"Ibyiza" na "demerits" bya fosifate gakondo
Ububiko bwa fosifate gakondo burimo cyane cyane karisiyumu irimo fosifate (nka calcium karubone na calcium acetate) hamwe na aluminiyumu irimo fosifate (nka hydroxide ya aluminium). Bahuza na fosifate mu biryo kugira ngo bibe ibintu bitangirika, bityo bigabanye amara ya fosifore.
Kalisiyumu irimo fosifate ihuza: Igiciro gito ningaruka zifatika zo kugabanya fosifore, ariko gukoresha igihe kirekire bishobora gutera hypercalcemia kandi byongera ibyago byo kubara kwamaraso.
Aluminium irimo fosifori ihuza: Ingaruka zikomeye zo kugabanya fosifore, ariko kwirundanya kwa aluminiyumu ni uburozi bukabije kandi birashobora gutera indwara ya aluminiyumu ifata amagufwa na encephalopathie, kandi kuri ubu ntabwo ikoreshwa cyane.
Lanthanum karubone: Kuzamuka mushya, hamwe nibyiza bigaragara
Lanthanum karubone ni karubone yibintu bidasanzwe byisi byitwa lanthanum, hamwe nuburyo bwihariye bwo guhuza fosifore. Irekura ioni ya lanthanum mubidukikije bya acide yinzira yigifu kandi ikora fosifate ya lanthanum idashobora gushonga hamwe na fosifate, bityo ikarinda kwinjiza fosifore.
Gutangiza muri make karubone ya lanthanum
| Izina ryibicuruzwa | Lanthanum karubone |
| Inzira | La2 (CO3) 3.xH2O |
| URUBANZA No. | 6487-39-4 |
| Uburemere bwa molekile | 457.85 (anhy) |
| Ubucucike | 2,6 g / cm3 |
| Ingingo yo gushonga | N / A. |
| Kugaragara | Ifu yera ya kirisiti |
| Gukemura | Gushonga mumazi, gushonga muburyo bugaragara muri acide minerval ikomeye |
| Igihagararo | Hygroscopic byoroshye |
Ugereranije na fosifore gakondo, karubone ya lanthanum ifite ibyiza bikurikira:
Nta calcium na aluminium, umutekano mwinshi: Irinde ibyago byo kurwara hypercalcemia nuburozi bwa aluminium, cyane cyane kubarwayi bafite imiti miremire kandi bafite ibyago byo kubara imitsi.
Ubushobozi bukomeye bwo guhuza fosifore, ingaruka zikomeye zo kugabanya fosifore: Carbone ya Lanthanum irashobora guhuza neza fosifore mu ntera yagutse ya pH, kandi ubushobozi bwayo bwo guhuza bukomeye kuruta guhuza fosifore gakondo.
Gastrointestinal reaction nkeya, kubahiriza neza umurwayi: Carbone ya Lanthanum iraryoshye, iroroshye kuyifata, ifite uburibwe buke bwa gastrointestinal, kandi abarwayi bakunze gukurikiza ubuvuzi bwigihe kirekire.
Ibimenyetso byubushakashatsi bwa Clinical: Lanthanum karubone ikora neza
Ubushakashatsi bwinshi bw’amavuriro bwemeje imikorere n’umutekano bya karubone ya lanthanum mu barwayi ba CKD. Ubushakashatsi bwerekanye ko karubone ya lanthanum itari munsi cyangwa ngo irusheho guhuza fosifate gakondo mu kugabanya urugero rwa fosifore mu maraso, kandi ishobora kugenzura neza urugero rwa iPTH no kunoza ibipimo byerekana amagufwa. Byongeye kandi, umutekano wokuvura igihe kirekire hamwe na karubone ya lanthanum nibyiza, kandi nta kwirundanya kwa lanthanum kugaragara hamwe nuburozi bwuburozi bwabonetse.
Kuvura kugiti cyawe: Hitamo gahunda nziza kumurwayi
Nubwo karubone ya lanthanum ifite ibyiza byinshi, ntibisobanura ko ishobora gusimbuza burundu fosifate gakondo. Buri muti ufite ibimenyetso byerekana kandi wanduye, kandi gahunda yo kuvura igomba kugirwa umuntu ukurikije uko umurwayi ameze.
Lanthanum karubone irakwiriye kubarwayi bakurikira:
Abarwayi bafite hypercalcemia cyangwa ibyago byo kurwara hypercalcemia
Abarwayi bafite calcium yimitsi cyangwa ibyago byo kubara imitsi
Abarwayi bafite kwihanganira nabi cyangwa imikorere mibi ya fosifate gakondo
Guhuza fosifate gakondo birashobora gukoreshwa kubarwayi bakurikira:
Abarwayi bafite ubukungu buke
Abarwayi bafite allergie cyangwa kutihanganira karubone ya lanthanum
Urebye ahazaza: Lanthanum karubone ifite ejo hazaza heza
Hamwe n’ubushakashatsi bwimbitse bw’ubuvuzi no kwegeranya uburambe mu buvuzi, imiterere ya karubone ya lanthanum mu kuvura hyperphosphatemia mu barwayi ba CKD izakomeza gutera imbere. Mu bihe biri imbere, karubone ya lanthanum iteganijwe guhinduka umurongo wa mbere wa fosifate, uzana inkuru nziza kubarwayi benshi ba CKD.
Igihe cyo kohereza: Werurwe-25-2025